Author

P. M. Kaye

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Biophysics· 1 Cancer Biology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Research Focus:host-pathogen & immune response· 4 Assay:imaging· 3 Organism:mouse· 3 Approach:statistical model· 3 Research Focus:cell-cell communication· 2 Organism:human· 2 Approach:microscopy & imaging analysis· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

H. Ashwin· 3 shared A. Romano· 2 shared J. S. P. Doehl· 2 shared M. Osman· 2 shared N. Brown· 2 shared N. S. Dey· 2 shared A. Aivazidis· 1 shared A. D. James· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersPathology

H. Ashwin

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Integrated histopathology, spatial and single cell transcriptomics resolve cellular drivers of early and late alveolar damage in COVID-19

J. T. H. Lee, S. N. Barnett, K. Roberts, H. Ashwin, L. Milross, J.-W. Cho, A. Huseynov, B. Woodhams, A. Aivazidis, T. Li, J. Majo, P. C. Guerrero, M. Lee, A. M. A. Miranda, Z. Jablonska, , O. A. Bayraktar

This study integrates single-cell and spatial transcriptomics with histopathology to identify cellular and molecular changes in lung alveolar damage during COVID-19 progression.

bioRxiv · Dec 20, 2023Pathology

Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

J. S. P. Doehl, H. Ashwin, N. Brown, A. Romano, S. Carmichael, J. W. Pitchford, P. M. Kaye

The paper uses spatial point pattern analysis to study parasite dispersal in L. donovani infection, revealing patchy distribution and spread through recruited myeloid cells.

bioRxiv · May 7, 2021Microbiology

Interferon-γ-producing CD4+ T cells drive monocyte activation in the bone marrow during experimental Leishmania donovani infection.

A. Romano, N. Brown, H. Ashwin, J. S. P. Doehl, J. Hamp, M. Osman, N. S. Dey, G. F. Rani, T. R. Ferreira, P. M. Kaye

This study shows CD4+ T cells produce IFN-γ to activate bone marrow monocytes during Leishmania donovani infection, enhancing parasite control.

bioRxiv · Apr 26, 2021Immunology

High speed, three-dimensional imaging reveals chemotactic behavior specific to human-infective Leishmania parasites

R. C. Findlay, M. Osman, K. Spence, P. M. Kaye, P. B. Walrad, L. G. Wilson

This study uses high-speed 3D imaging to show that Leishmania parasites change their swimming behavior during their lifecycle, with specific adaptations for infecting humans.

bioRxiv · Jul 30, 2020Biophysics

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

N. S. Dey, S. Senarathna, V. Somaratne, N. Madarasinghe, B. Seneviratne, S. S. Forrester, M. Montes De Oca, L. C. Reis, S. Moulik, P. Walrad, M. Chatterjee, H. Goto, R. Wickremasinghe, D. Lagos, P. M. Kaye, S. Ranasinghe

The paper identifies early reduction in PD-L1 expression as a predictor of faster treatment response to SSG in Sri Lankan cutaneous leishmaniasis patients.

bioRxiv · Feb 21, 2020Immunology

Metastatic breast cancer cells induce altered microglial morphology and electrical excitability in vivo

A. Simon, M. Yang, J. L. Marrison, A. D. James, P. J. O'Toole, P. M. Kaye, M. A. Whittington, S. Chawla, W. Brackenbury

This study shows metastatic breast cancer cells alter microglial morphology and electrical activity in the brain, contributing to seizures and cognitive issues.

bioRxiv · May 14, 2019Cancer Biology