Author

D. Lagos

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

B. Cartes-Saavedra· 1 shared B. Seneviratne· 1 shared C. Vasquez-Trincado· 1 shared D. Boucher· 1 shared G. Aedo· 1 shared G. Vidal· 1 shared H. Goto· 1 shared I. Molina-Riquelme· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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1 shared paperCell Biology

B. Cartes-Saavedra

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

OPA1 and disease-causing mutants perturb mitochondrial nucleoid distribution

J. Macuada, I. Molina-Riquelme, G. Vidal, N. Perez-Bravo, C. Vasquez-Trincado, G. Aedo, D. Lagos, R. Horvath, T. J. Rudge, B. Cartes-Saavedra, V. Eisner

This study investigates how OPA1 and its disease-causing mutants affect mitochondrial nucleoid distribution using high-resolution microscopy and a novel model.

bioRxiv · Feb 1, 2024Cell Biology

Mathematical modelling of activation-induced heterogeneity reveals cell state transitions underpinning macrophage responses to LPS

S. Dey, D. Boucher, J. W. Pitchford, D. Lagos

The paper uses mathematical modeling and single-cell data to show how macrophage heterogeneity under LPS drives primary and secondary responses, with hypo-responsiveness linked to state transitions in a 3- or 4-state model.

bioRxiv · Sep 19, 2021 · PreprintImmunology

Early reduction in PD-L1 expression predicts faster treatment response in human cutaneous leishmaniasis

N. S. Dey, S. Senarathna, V. Somaratne, N. Madarasinghe, B. Seneviratne, S. S. Forrester, M. Montes De Oca, L. C. Reis, S. Moulik, P. Walrad, M. Chatterjee, H. Goto, R. Wickremasinghe, D. Lagos, P. M. Kaye, S. Ranasinghe

The paper identifies early reduction in PD-L1 expression as a predictor of faster treatment response to SSG in Sri Lankan cutaneous leishmaniasis patients.

bioRxiv · Feb 21, 2020Immunology