N. Brown

Mechanisms of USP18 deISGylation revealed by comparative analysis with its human paralog USP41

This study identifies molecular determinants of USP18's specificity for ISG15 through comparative analysis with its paralog USP41, revealing structural features essential for enzymatic activity.

Macrophage-derived developmental endothelial locus 1 (DEL-1) expression promotes an immunoprotective phenotype in experimental visceral leishmaniasis.

This study shows that DEL-1 expression in macrophages reduces parasite burden and granuloma formation in visceral leishmaniasis, promoting an immunoprotective response.

Heterogeneous distribution of kinesin-streptavidin complexes revealed by Mass Photometry

The paper uses mass photometry to show heterogeneous distributions of kinesin-streptavidin complexes, attributing this to mixing ratios and biotinylation efficiency.

The long and short of it: Benchmarking viromics using Illumina, Nanopore and PacBio sequencing technologies

This paper benchmarks viromics using Illumina, Nanopore, and PacBio sequencing technologies to assess their impact on viral community reconstruction and error rates.

UVB modifies skin immune-stroma cross-talk and promotes effector T cell recruitment during cryptic Leishmania donovani infection

This study uses scRNA-seq and spatial transcriptomics to show UVB exposure alters immune-stromal interactions and T cell recruitment during cryptic Leishmania donovani infection.

Laboratory evaluation of a quaternary ammonium compound (QAC)-based antimicrobial coating used in public transport during the COVID-19 pandemic

This study evaluates the virucidal activity of a QAC-based antimicrobial coating on various materials, finding reduced efficacy with organic debris and limited effectiveness in real-world settings.

Higher aboveground carbon stocks in mixed-species planted forests than monocultures - a meta-analysis

This study finds mixed-species planted forests store more aboveground carbon than monocultures, with higher carbon stocks in more diverse mixtures.

Spatial point pattern analysis identifies mechanisms shaping the skin parasite landscape in Leishmania donovani infection

The paper uses spatial point pattern analysis to study parasite dispersal in L. donovani infection, revealing patchy distribution and spread through recruited myeloid cells.

INfrastructure for a PHAge REference Database: Identification of large-scale biases in the current collection of phage genomes

The paper develops a tool to extract phage genomes and identifies biases in their representation, such as overrepresentation of lytic phages and limited host diversity.

Interferon-γ-producing CD4+ T cells drive monocyte activation in the bone marrow during experimental Leishmania donovani infection.

This study shows CD4+ T cells produce IFN-γ to activate bone marrow monocytes during Leishmania donovani infection, enhancing parasite control.

On-off transition and ultrafast decay of amino acid luminescence driven by modulation of supramolecular packing

This study investigates amino acid luminescence in aggregated states, finding that supramolecular packing, not chemical properties, drives visible light emission and reversible optical transitions.

Analysis of selection methods to develop novel phage therapy cocktails against antimicrobial resistant clinical isolates of bacteria

This paper evaluates selection methods for developing phage cocktails against ESBL-producing bacteria, finding that planktonic killing assays are effective and efficient for identifying effective phages.

Protein Targets of Inositol Pyrophosphate (5-IP7) in the parasite Trypanosoma cruzi

This study identifies 5-IP7 protein targets in Trypanosoma cruzi using affinity pull-down and mass spectrometry, revealing distinct target profiles in different proliferative stages and potential therapeutic targets.

Effects of exposure to sublethal concentrations of methoxyfenozide on honey bee colony activity and thermoregulation

This study examines the effects of sublethal methoxyfenozide exposure on honey bee colony activity and thermoregulation, finding significant behavioral changes at higher concentrations.

Salmonella effectors SseK1 and SseK3 target death domain proteins in the TNF and TRAIL signaling pathways

This study identifies that Salmonella effectors SseK1 and SseK3 glycosylate death domain proteins in TNF and TRAIL signaling pathways, modulating their function during infection.