Lathosterol oxidase (sterol C5-desaturase) deletion confers resistance to amphotericin B and sensitivity to acidic stress in Leishmania major
Y. Ning, C. Frankfater, F.-F. Hsu, R. Soares, C. Cardoso, P. Nogueira, N. Lander, R. Docampo, K. Zhang
This study shows that deleting LSO in Leishmania major confers amphotericin B resistance but causes sensitivity to acidic stress and membrane disruption.
bioRxiv · Apr 20, 2020Microbiology