Single-molecule studies reveal the off-pathway elemental pause state as a target of streptolydigin inhibition of RNA polymerase and its dramatic enhancement by Gre factors
A. Arseniev, M. Panfilov, G. Pobegalov, A. Potyseva, P. Pavlinova, M. Yakunina, J. Lee, S. Borukhov, K. Severinov, M. Khodorkovskii
This study uses single-molecule techniques to show streptolydigin induces pauses in RNA polymerase, which are enhanced by Gre factors, revealing a new mechanism for antibiotic action.
bioRxiv · Jun 5, 2023 · PreprintBiophysics