Author

M. Khodorkovskii

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Organism:bacteria (other)· 3 Approach:experimental assay· 3 Assay:DNA methylation· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

A. Arseniev· 2 shared K. Severinov· 2 shared A. Alekseev· 1 shared A. Kirillov· 1 shared A. Potyseva· 1 shared A. Vasileva· 1 shared G. Pobegalov· 1 shared I. Frantsuzova· 1 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiophysics

A. Arseniev

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Catalytically inactive dKbCas12d guided by sgRNA and new insights into its binding through a single-molecule approach

A. Alekseev, V. Klimko, I. Frantsuzova, M. Abramova, V. Vinnik, A. Vasileva, P. Selkova, M. Khodorkovskii, A. Arseniev

The paper describes modifications to the CRISPR-Cas12d system, identifies catalytically inactive variants, and demonstrates their high specificity using single-molecule techniques.

bioRxiv · Dec 12, 2023 · PreprintBiophysics

Single-molecule studies reveal the off-pathway elemental pause state as a target of streptolydigin inhibition of RNA polymerase and its dramatic enhancement by Gre factors

A. Arseniev, M. Panfilov, G. Pobegalov, A. Potyseva, P. Pavlinova, M. Yakunina, J. Lee, S. Borukhov, K. Severinov, M. Khodorkovskii

This study uses single-molecule techniques to show streptolydigin induces pauses in RNA polymerase, which are enhanced by Gre factors, revealing a new mechanism for antibiotic action.

bioRxiv · Jun 5, 2023 · PreprintBiophysics

Cells with Stochastically Increased Methyltransferase to Restriction Endonuclease Ratio Provide an Entry for Bacteriophage into Protected Cell Population

A. Kirillov, N. Morozova, V. Polinovaskaya, S. Smirnov, M. Khodorkovskii, L. Zeng, Y. Ispolatov, K. Severinov

The paper shows that altering the MTase to REase ratio in bacterial cells affects phage infection resistance, with higher ratios correlating with increased susceptibility.

bioRxiv · Mar 28, 2022Microbiology