MicrobiologybioRxiv
Lethality of SARS-CoV-2 infection in K18 human angiotensin converting enzyme 2 transgenic mice
F. Oladunni, J.-G. Park, P. Pino Tamayo…·J. B. Torrelles
This study demonstrates that K18 hACE2 transgenic mice are susceptible to SARS-CoV-2 infection, exhibit cytokine and chemokine storms, and serve as a model for studying viral pathogenesis and therapeutic development.
DOI 10.1038/s41467-020-19891-7