SARS-CoV-2 Viroporins Activate The NLRP3-Inflammasome Via The Mitochondrial Permeability Transition Pore
J. W. Guarnieri, A. Angelin, D. G. Murdoch, P. Portluri, T. Lie, D. C. Wallace
This study shows SARS-CoV-2 viroporins E and Orf3a increase mitochondrial calcium and reactive oxygen species, which activate the NLRP3 inflammasome via the mitochondrial permeability transition pore.
bioRxiv · Feb 19, 2022 · PreprintImmunology