DNA methylation classification in diffuse glioma shows little spatial heterogeneity after adjusting for tumor purity
N. Verburg, F. P. Barthel, K. J. Anderson, K. C. Johnson, M. Koopman, M. Yaqub, O. Hoekstra, A. Lammertsma, F. Barkhof, P. Pouwels, J. C. Reijneveld, A. Rozemuller, R. Boellaard, M. D. Taylor, S. Das, , R. G. Verhaak
This study shows DNA methylation subtypes in diffuse gliomas are spatially consistent after adjusting for tumor purity, indicating inherent cellular heterogeneity rather than tumor-specific variation.
bioRxiv · Mar 28, 2020 · PreprintCancer Biology