Author

K. C. Johnson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 6 Biochemistry· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 7 Research Focus:differential expression· 6 Approach:statistical model· 5 Research Focus:cell type annotation· 4 Assay:DNA methylation· 4 Assay:bulk RNA-seq· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

H. Kim· 4 shared R. G. Verhaak· 4 shared F. P. Barthel· 3 shared F. S. Varn· 3 shared K. J. Anderson· 3 shared S. Das· 3 shared E. Yi· 2 shared N. Verburg· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersCancer Biology

H. Kim

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Nuclear Localization of Argonaute is affected by Cell Density and May Relieve Repression by microRNAs

K. C. Johnson, A. Kilikevicius, C. Hofman, J. Hu, Y. Liu, S. Aguilar, C. Graswich, Y. Han, T. Wang, J. Wescott, R. A. Brekken, L. Peng, G. Karagkounis, D. R. Corey

This study shows that nuclear localization of AGO2 in HCT116 cells and human colon tumors can de-repress miRNA targets and enhance cell migration, influenced by cell density, miRNA biogenesis, and miRISC components.

bioRxiv · Jul 7, 2023Biochemistry

Longitudinal analysis of diffuse glioma reveals cell state dynamics at recurrence associated with changes in genetics and the microenvironment

F. S. Varn, K. C. Johnson, T. E. Wade, T. M. Malta, T. S. Sabedot, F. P. Barthel, H. Kim, N. Ahmed, I. Datta, J. S. Barnholtz-Sloan, S. Bakas, F. D'Angelo, H. K. Gan, L. Garofano, J. T. Huse, , The GLASS Consortium

This study analyzes longitudinal glioma data to identify recurrence-associated changes in genetics and microenvironment linked to therapy resistance.

bioRxiv · May 3, 2021Cancer Biology

Live-cell imaging shows uneven segregation of extrachromosomal DNA elements and transcriptionally active extrachromosomal DNA clusters in cancer

E. Yi, A. D. Gujar, M. Guthrie, H. Kim, K. C. Johnson, S. B. Amin, S. Das, P. A. Clow, A. W. Cheng, R. G. Verhaak

The paper uses live-cell imaging to show uneven ecDNA segregation and transcriptional clustering in cancer cells, explaining ecDNA accumulation and oncogenesis.

bioRxiv · Oct 20, 2020 · PreprintCancer Biology

Single-cell multimodal glioma analyses reveal epigenetic regulators of cellular plasticity and environmental stress response

K. C. Johnson, K. J. Anderson, E. T. Courtois, F. Barthel, F. S. Varn, D. Luo, M. Seignon, E. Yi, H. Kim, M. Estecio, M. Tang, N. Navin, R. Maurya, C. Ngan, N. Verburg, , R. Verhaak

The paper integrates multi-omic data from gliomas to show that epigenetic instability and transcriptional disruption are linked to tumor aggressiveness and environmental stress response.

bioRxiv · Jul 22, 2020Cancer Biology

DNA methylation classification in diffuse glioma shows little spatial heterogeneity after adjusting for tumor purity

N. Verburg, F. P. Barthel, K. J. Anderson, K. C. Johnson, M. Koopman, M. Yaqub, O. Hoekstra, A. Lammertsma, F. Barkhof, P. Pouwels, J. C. Reijneveld, A. Rozemuller, R. Boellaard, M. D. Taylor, S. Das, , R. G. Verhaak

This study shows DNA methylation subtypes in diffuse gliomas are spatially consistent after adjusting for tumor purity, indicating inherent cellular heterogeneity rather than tumor-specific variation.

bioRxiv · Mar 28, 2020 · PreprintCancer Biology

Comparative molecular life history of spontaneous canine and human gliomas

S. B. Amin, K. J. Anderson, C. E. Boudreau, E. Martinez-Ledesma, E. Kocavakuk, K. C. Johnson, F. P. Barthel, F. S. Varn, C. Kassab, X. Ling, H. Kim, M. Barter, C. Y. Ngan, M. Chapman, J. W. Koehler, , R. G. Verhaak

This study compares molecular profiles of canine and human gliomas to identify conserved mutational processes and similarities in tumor development.

bioRxiv · Jun 17, 2019Cancer Biology

Longitudinal Study of Leukocyte DNA Methylation and Biomarkers for Cancer Risk in Older Adults

A. H. Bartlett, J. W. Liang, J. V. Sandoval-Sierra, J. H. Fowke, E. M. Simonsick, K. C. Johnson, K. Mozhui

This study examines longitudinal changes in DNA methylation in leukocytes and identifies CpG sites associated with cancer risk in older adults.

bioRxiv · Apr 3, 2019Cancer Biology