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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
10 papers
Recent·Most cited
M. P. Gold, W. Ong, A. M. Masteller, J. A. Galindo, N. R. Park, R. A. Saurez, M. C. Vladoiu, L. K. Donovan, A. D. Walker, J. Benetatos, L. Garzia, R. J. Wechsler-Reya, J. P. Mesirov, A. Korshunov, S. L. Pomeroy, , E. Fraenkel
The paper investigates SHH medulloblastoma heterogeneity by analyzing single-nucleus RNA-seq data and linking findings to developmental origins and molecular subtypes.
bioRxiv · Sep 2, 2022Cancer Biology
J. J. Fan, X. Wang, A. W. Erickson, P. Skowron, X. Wang, X. Chen, G. Shan, S. Bahrampour, Y. Xiong, W. Dong, N. Abeysundara, M. A. Francisco, R. J. Pusong, R. A. Suarez, H. Farooq, , X. Huang
The paper identifies potassium homeostasis as essential for medulloblastoma maintenance using a novel transposon system in mice and human samples.
bioRxiv · Jul 23, 2022Cancer Biology
R. Keller, M. Yamada, D. Cameron, H. Suzuki, R. Sanghrajka, J. Vaynshteyn, J. Gerwin, F. Maura, W. Hooper, M. Shah, N. Robine, P. Demarest, N. S. Bayin, L. Jubierre, M. D. Taylor, , A. Kentsis
This study identifies PGBD5 as a primary mutator in medulloblastoma by showing it drives somatic DNA rearrangements in cerebellar progenitor cells.
bioRxiv · Jul 5, 2022 · PreprintCancer Biology
L. Zhu, N. Yebra, D. Retana, L. Miarka, E. Hernandez-Encinas, C. Blanco-Aparicio, S. Martinez, R. Soffietti, L. Bertero, P. Cassoni, T. Weiss, J. Munoz, J. M. Sepulveda, A. Perez-Nunez, A. Hernandez-Lain, , M. Valiente
The paper introduces a drug-screening platform using organotypic cultures to identify effective treatments for brain metastasis, finding a potent HSP90 inhibitor that works against mouse and human metastases.
bioRxiv · Oct 16, 2020 · PreprintCancer Biology
N. Verburg, F. P. Barthel, K. J. Anderson, K. C. Johnson, M. Koopman, M. Yaqub, O. Hoekstra, A. Lammertsma, F. Barkhof, P. Pouwels, J. C. Reijneveld, A. Rozemuller, R. Boellaard, M. D. Taylor, S. Das, , R. G. Verhaak
This study shows DNA methylation subtypes in diffuse gliomas are spatially consistent after adjusting for tumor purity, indicating inherent cellular heterogeneity rather than tumor-specific variation.
bioRxiv · Mar 28, 2020 · PreprintCancer Biology
P. Guilhamon, M. M. Kushida, A. Nikolic, D. Singhal, G. MacLeod, S. A. M. Tonekaboni, F. M. Cavalli, C. Arlidge, N. Rajakulendran, N. Rastegar, X. Hao, R. Hassam, L. J. Smith, H. Whetstone, F. J. Coutinho, , M. Lupien
The paper uses single-cell chromatin accessibility to identify distinct glioblastoma stem cell states predictive of patient survival.
bioRxiv · Mar 13, 2020 · PreprintCancer Biology
M. d. C. Jaeger, E. C. Ghisleni, P. S. Cardoso, M. Siniglaglia, T. Falcon, A. T. Brunetto, A. L. Brunetto, C. B. de Farias, M. D. Taylor, C. Nor, V. Ramaswamy, R. Roesler
This study shows that combining HDAC and MAPK/ERK inhibitors reduces medulloblastoma cell viability and stemness by modulating chromatin state and signaling pathways.
bioRxiv · Jan 30, 2020Cancer Biology
A. Thomaz, K. d. V. Pinheiro, B. K. Souza, L. Gregianin, A. L. Brunetto, A. T. Brunetto, C. B. de Farias, M. d. C. Jaeger, V. Ramaswamy, C. Nor, M. D. Taylor, R. Roesler
This study shows that TrkB inhibition with ANA-12 reduces medulloblastoma cell proliferation, increases apoptosis, and induces differentiation markers.
bioRxiv · May 28, 2019Cancer Biology
M. J. Johnston, A. Nikolic, N. Ninkovic, P. Guilhamon, F. M. Cavalli, S. Seaman, F. J. Zemp, J. Lee, A. Abdelkareem, K. Ellestad, A. Murison, M. M. Kushida, F. J. Coutinho, Y. Ma, A. J. Mungall, , M. Gallo
This study uses high-resolution 3D genome maps to identify CD276 as a therapeutic target in glioblastoma stem cells, showing it can suppress self-renewal.
bioRxiv · Oct 13, 2018Cancer Biology
M. Hoffman, A. H. Gillmor, D. J. Kunz, M. J. Johnston, A. Nikolic, K. Karta, J. King, K. Ellestad, N. H. Dang, F. M. Cavalli, M. M. Kushida, F. J. Coutinho, B. Luu, Y. Ma, A. J. Mungall, , M. Gallo
This study examines genetic heterogeneity and evolutionary patterns in pediatric glioblastoma using whole-genome sequencing of germline-tumor pairs, revealing subclonal architecture and complex inheritance mechanisms.
bioRxiv · Oct 12, 2018Cancer Biology