Biological Evaluation of Molecules of the azaBINOL Class as Antiviral Agents: Specific Inhibition of HIV-1 RNase H Activity by 7-Isopropoxy-8-(naphth-1-yl)quinoline
R. D. Overacker, S. Banerjee, G. F. Neuhaus, S. Milicevic Sephton, A. Herrmann, J. A. Strother, R. Brack-Werner, P. R. Blakemore, S. Loesgen
This study evaluates azaBINOL compounds as antiviral agents, identifying 7-isopropoxy-8-(naphth-1-yl)quinoline as a low-micromolar inhibitor of HIV-1 RNase H activity.
bioRxiv · Jan 23, 2019Pharmacology & Toxicology