Megakaryocyte TGFβ1 Partitions Hematopoiesis into Immature Progenitor/Stem Cells and Maturing Precursors
S. Di Giandomenico, P. Rabbany, N. Molle, M. Yabut, G. A. Zeinah, T. Stephens, N. Messali, S. Rafii, J. M. Scandura
This study shows that megakaryocyte-derived TGFβ1 controls hematopoiesis by regulating immature HSPC pools and erythroid precursor survival, improving erythropoiesis efficiency.
bioRxiv · Jul 6, 2019 · PreprintCell Biology