Identification and validation of E3 ubiquitin ligase XIAP as a novel substrate of deubiquitinase USP7 (HAUSP) - Implication towards oncogenesis
G. Saha, S. Sarkar, P. S. Mohanta, K. Kumar, S. Chakrabarti, M. K. Ghosh
This study identifies XIAP as a novel substrate of USP7, showing that USP7 stabilizes XIAP to promote tumorigenesis by inhibiting apoptosis, and finds that combined inhibition of USP7 and XIAP enhances apoptosis.
bioRxiv · Aug 12, 2021 · PreprintCancer Biology