S. Chakrabarti

Dual-specific autophosphorylation of kinase IKK2 enables phosphorylation of substrate IκBα through a phosphoenzyme intermediate

This study identifies dual-specific autophosphorylation in IKK2, showing tyrosine autophosphorylation and ATP-contacting residue K44 regulate substrate specificity for IκBα phosphorylation during NF-κB activation.

CircRNA_012164/MicroRNA-9-5p axis mediates cardiac fibrosis in diabetic cardiomyopathy

This study identifies a circRNA_012164/miR9-5p axis that promotes cardiac fibrosis in diabetic cardiomyopathy through regulation of fibrotic gene expression.

Combining lineage correlations and a small molecule inhibitor to detect circadian control of the cell cycle.

The paper uses lineage correlations and a small molecule inhibitor to detect circadian control of the cell cycle in colon cancer cells.

The Lion's Share: Implications of carnivore diet on endangered herbivores in Tsavo

The paper analyzes lion diet in Tsavo, Kenya, finding that lions disproportionately consume endangered hirola and Grevys zebra despite their low population sizes.

Eating an elephant, one bite at a time: predator interactions at carrion bonanzas

The paper studies predator interactions at elephant carcasses using remote cameras, finding interference competition among terrestrial predators and unique feeding behaviors at aquatic interfaces.

Eat or Be Eaten: Implications of potential exploitative competition between wolves and humans across predator- savvy and -naive deer populations

The study examines how wolf presence affects deer behavior in areas with and without wolves, finding that deer in wolf-present areas show reduced activity and increased vigilance in dense vegetation, while naive deer in wolf-absent areas do not respond similarly.

Diffusion controls local versus dispersed inheritance of histones during replication and shapes epigenomic architecture

The paper develops a stochastic model of histone dynamics at the replication fork, showing that differential diffusivity explains histone inheritance patterns and predicts epigenomic patterns observed in experiments.

Prioritizing landscapes to reconcile biodiversity conservation, ecosystem services, and human well-being in India

This study identifies priority landscapes in India for biodiversity conservation and ecosystem services that align with human well-being, finding that current protected areas cover only 15% of these regions.

Modulation of RNA binding properties of the RNA helicase UPF1 by its activator UPF2

This study shows that UPF2 binding reduces UPF1's RNA affinity, causing RNA release through an allosteric effect rather than direct competition.

Intrinsically disordered regions of Tristetraprolin and DCP2 directly interact to mediate decay of ARE-mRNA

This study identifies a direct interaction between TTP and DCP2 involving intrinsically disordered regions that influences ARE-mRNA stability.

Particle Uptake Driven Phagocytosis in Macrophages and Neutrophils Enhances Bacterial Clearance

This study shows that non-stimulatory cargo-free particles enhance phagocytic ability in macrophages and neutrophils, leading to faster bacterial clearance.

Identification and validation of E3 ubiquitin ligase XIAP as a novel substrate of deubiquitinase USP7 (HAUSP) - Implication towards oncogenesis

This study identifies XIAP as a novel substrate of USP7, showing that USP7 stabilizes XIAP to promote tumorigenesis by inhibiting apoptosis, and finds that combined inhibition of USP7 and XIAP enhances apoptosis.

Lipid Droplets Promote Phase Separation of Ago2 to Accelerate Dicer1 Loss and Decelerate miRNA Activity in Lipid Exposed Hepatic Cells

The paper shows lipid droplets promote Ago2 phase separation, reduce Dicer1 levels, and decrease miR-122 activity in hepatic cells under lipotoxic stress.

Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including Thymic Epithelial Cells

The paper identifies BM-derived CD45+EpCAM+ cells that contribute to thymic stroma and TEC maintenance, challenging the notion that these cells originate solely from endoderm.

Origin and Evolution of DNA methyltransferases (DNMT) along the tree of life: A multi-genome survey.

This study systematically surveys the evolution of DNA methyltransferases across different lineages, finding increased sequence conservation and complexity in vertebrates.

In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3

The paper identifies guanabenz and sephin1 as new allosteric modulators of ASIC3 through in silico screening of FDA-approved drugs and electrophysiological validation.

A systematic investigation on the involvement of complement pathway in diabetic retinopathy

This study investigates the role of the complement pathway in diabetic retinopathy, finding increased activation of the alternative pathway and co-localization of CFH with microglial cells.

The material properties of naked mole-rat hyaluronan

This study investigates the structural and material properties of hyaluronan from naked mole-rats, revealing unique folded structures and gel-forming capabilities that may contribute to their cancer resistance and skin elasticity.

Processivity, velocity and universal characteristics of nucleic acidunwinding by helicases

This study derives analytic expressions for helicase velocity and processivity, showing processivity increases with force and reveals T7 is a weakly active helicase with high back-stepping probability.

Molecular chaperones maximize the native state yield per unit time by driving substrates out of equilibrium

The paper develops a stochastic model to explain how molecular chaperones maximize native state production rates by driving substrates out of equilibrium, reconciling conflicting experimental results on ribozyme and protein folding.

Protein Collapse is Encoded in the Folded State Architecture

The paper develops a polymer physics-based theory to assess protein collapsibility using contact maps, showing that beta-sheet proteins are more collapsible than alpha-helical ones and explaining the origin of multi-domain proteins.