Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1
G. Gaullier, G. Roberts, U. M. Muthurajan, S. Bowerman, J. Rudolph, J. Mahadevan, A. Jha, P. S. Rae, K. Luger
The paper presents a cryo-EM structure of PARP2 bridging nucleosome-proximal DNA breaks and shows its interaction with HPF1 in a functional complex.
bioRxiv · Nov 18, 2019Biochemistry