Author

U. M. Muthurajan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:cryo-EM· 1 Organism:human· 1

Frequent Co-Authors

G. Roberts· 2 shared J. Rudolph· 2 shared K. Luger· 2 shared A. Jha· 1 shared G. Gaullier· 1 shared J. Mahadevan· 1 shared P. S. Rae· 1 shared S. Bowerman· 1 shared

Activity by Year

2019-2021 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

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2 shared papersBiochemistry

G. Roberts

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2 papers

Recent·Most cited

BiochemistryeLifePeer-reviewedMar 8, 2021

HPF1 and nucleosomes mediate a dramatic switch in activity of PARP1 from polymerase to hydrolase

J. Rudolph, G. Roberts, U. M. Muthurajan, K. Luger

This study investigates how HPF1 modulates PARP1 activity, switching it from polymerase to hydrolase, and shows HPF1's role in redirecting PARylation and affecting PAR chain length.

DOI 10.7554/elife.65773

experimental assaycell signaling & trafficking

𝕏 PostBluesky

BiochemistrybioRxivNov 18, 2019

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1

G. Gaullier, G. Roberts, U. M. Muthurajan…·K. Luger

The paper presents a cryo-EM structure of PARP2 bridging nucleosome-proximal DNA breaks and shows its interaction with HPF1 in a functional complex.

DOI 10.1371/journal.pone.0240932

humancryo-EM

𝕏 PostBluesky