A. Jha

Assessment of Nutrient Composition and utilization of some popular wild Edible fruits of Kumaun Himalayan Region as Anti-oxidant agents

This study evaluates the nutrient composition and antioxidant potential of six wild edible fruits from the Kumaun Himalayan region, identifying Diospyros kaki and Rubus niveus as promising sources of antioxidants and micronutrients.

Falcon gut microbiome is shaped by diet and enriched in Salmonella

This study examines the gut microbiota of falcons, finding that diet shapes their microbiome and that Salmonella is prevalent, potentially affecting gut function and human health.

Zmiz1 is required for mature β-cell function and mass expansion upon high fat feeding

This study shows that Zmiz1 is essential for β-cell function and mass expansion in response to high fat feeding, linking its loss to diabetes.

Dynamics of endogenous PARP1 and PARP2 during DNA damage revealed by live-cell single-molecule imaging

This study uses live-cell single-molecule imaging to show that most PARP1/2 diffuse freely, with a small fraction transiently binding DNA after damage, suggesting new strategies for PARP inhibitors.

Dynamics of CTCF and cohesin mediated chromatin looping revealed by live-cell imaging

This study uses live-cell imaging to show that chromatin loops at the Fbn2 TAD are rare and dynamic, challenging the notion of stable TADs.

Identifying common transcriptome signatures of cancer by interpreting deep learning models

This study identifies common transcriptome signatures across cancer types using deep learning models trained on RNA-Seq data, revealing genes and splicing variations associated with cancer.

Pyruvate kinase M1 suppresses development and progression of prostate adenocarcinoma

The paper investigates the role of pyruvate kinase isoforms in prostate cancer, finding that Pkm1 suppresses cancer while Pkm2 promotes it, and that a PKM1-like activator can suppress tumor progression.

Topical TMPRSS2 inhibition prevents SARS-CoV-2 infection in differentiated primary human airway cells

This study shows topical camostat mesylate inhibits SARS-CoV-2 infection in human airway cells, suggesting it could be used for pre- or post-exposure prophylaxis.

NCoR1 and SMRT fine-tune inflammatory versus tolerogenic balance in dendritic cells by differentially regulating STAT3 signaling

This study shows SMRT and NCoR1 regulate inflammatory and tolerogenic responses in dendritic cells by modulating STAT3 signaling and cytokine expression.

GABARAP membrane conjugation sequesters the FLCN-FNIP tumor suppressor complex to activate TFEB and lysosomal biogenesis

Evolutionary Emergence of First Animal Organisms Triggered by Environmental Mechano-Biochemical Marine Stimulation

Marine hydrodynamic strains activated gastric organ formation from ancestral pre-animal cell colonies through mechanotransduction.

Bridging of nucleosome-proximal DNA double-strand breaks by PARP2 enhances its interaction with HPF1

The paper presents a cryo-EM structure of PARP2 bridging nucleosome-proximal DNA breaks and shows its interaction with HPF1 in a functional complex.

Environmental niche forecasts of globally threatened Yellow-throated Bulbul, Pycnonotus xantholaemus for conservation prospects in the Deccan peninsula, India

The paper uses environmental niche modeling to predict suitable habitats for the Yellow-throated Bulbul in India and highlights conservation concerns.

Widespread alteration of protein autoinhibition in human cancers

The paper identifies cancer-specific mutations in inhibitory allosteric switches across multiple cancer types and shows their association with altered signaling and cancer progression.

Q-FADD: A mechanistic approach for modeling the accumulation of proteins at sites of DNA damage by free diffusion

The paper introduces a free diffusion model to quantify protein accumulation at DNA damage sites in live cells, applied to poly-ADP-ribose polymerases 1 and 2.