P. Sinharoy

E-cigarette aerosol exacerbates cardiovascular oxidative stress in mice with an inactive aldehyde dehydrogenase 2 enzyme

This study shows that e-cigarette aerosol increases cardiovascular oxidative stress in mice with the ALDH2*2 genetic variant, leading to higher ROS, protein damage, and NF-kB activation.

Targeting Reactive Aldehyde Detoxification by Aldehyde Dehydrogenase 2 (ALDH2) as a Treatment Strategy for Endometriosis

This study shows that reduced ALDH2 activity contributes to endometriosis and pain, and that increasing ALDH2 activity can prevent lesion development and alleviate pain.