F. Xiao

Flux exponent control predicts metabolic dynamics from network structure

This paper introduces flux exponent control (FEC), a constraint-based method to model dynamic metabolic fluxes from network structure, demonstrating its application to glycolysis dynamics.

A novel triptolide analog downregulates NF-κB and induces mitochondrial apoptosis pathways in human pancreatic cancer

This paper describes a novel triptolide analog, CK21, which downregulates the NF-κB pathway and induces mitochondrial apoptosis in human pancreatic cancer cells.

Reduced Neutralization of SARS-CoV-2 Omicron Variant in Sera from SARS-CoV-1 Survivors after 3-dose of Vaccination

This study shows that SARS-CoV-1 survivors vaccinated with ZF2001 have reduced neutralization against SARS-CoV-2 Omicron compared to other variants.

Dissecting Mutational Allosteric Effects in Alkaline Phosphatases Associated with Different Hypophosphatasia Phenotypes: An Integrative Computational Investigation

This paper uses computational methods to analyze ALPL mutations in Hypophosphatasia, finding that severe mutations significantly affect allosteric communications and protein stability.

E-cigarette aerosol exacerbates cardiovascular oxidative stress in mice with an inactive aldehyde dehydrogenase 2 enzyme

This study shows that e-cigarette aerosol increases cardiovascular oxidative stress in mice with the ALDH2*2 genetic variant, leading to higher ROS, protein damage, and NF-kB activation.

Angiocrine IGFBP3 Spatially Coordinates IGF Signaling During Neonatal Cardiac Regeneration

The paper identifies IGFBP3 as a secreted protein that spatially coordinates IGF signaling to promote neonatal cardiac regeneration.

The ORF8 Protein of SARS-CoV-2 Mediates Immune Evasion through Potently Downregulating MHC-I

This study identifies SARS-CoV-2 ORF8 as a protein that downregulates MHC-I to evade immune detection by promoting lysosomal degradation, reducing CTL-mediated cell elimination.

Modulating the selective utilization of carbon sources by engineering the 3rd and 4th helices of the DNA-binding domain of catabolite control protein A (CcpA) in Bacillus licheniformis

This study investigates how specific amino acids in the DNA-binding domain of CcpA affect carbon source utilization in Bacillus licheniformis through in vitro and in vivo experiments.

Integration of embryo-endosperm interaction into a holistic and dynamic picture of seed development using a rice mutant with notched-belly grains

The paper investigates embryo-endosperm signaling in rice using a mutant to identify regulatory pathways affecting endosperm development and proposes a new staging system for rice seed development.

Simulations of fluorescence imaging in the oral cavity

The paper simulates fluorescence imaging in the oral cavity using a 3D model and compares simulated data with real camera data to quantify porphyrin fluorescence relative to other fluorophores.

Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

This study identifies NMD as a vulnerability in cancer cells with SF3B1 and U2AF1 mutations, showing increased sensitivity to NMD inhibition and potential therapeutic targeting.

Adducin Regulates Sarcomere Disassembly During Cardiomyocyte Mitosis

This study identifies adducin as a regulator of sarcomere disassembly during cardiomyocyte mitosis, showing phosphorylation of a short isoform induces disassembly in neonatal cardiomyocytes.

Isothermal Amplification of Nucleic Acids with Ladder-shape Melting Curve

The paper develops a novel isothermal amplification method (LMCP) for detecting Oryza sativa ITS with higher sensitivity and speed compared to LAMP.

A Fast Lysine Cross-linker DOPA Enables Mass Spectrometry Analyses of Protein Unfolding and Weak Protein-protein Interactions

This study introduces a fast lysine cross-linker DOPA for mass spectrometry analyses, showing it enables rapid protein cross-linking and captures dynamic conformational changes and weak protein-protein interactions.

Proofreading through spatial gradients

This paper proposes a spatial gradient-based error correction mechanism that enhances specificity without requiring dedicated structural features, and quantifies its performance limitations.

Paxillin Promotes ATP-induced Activation of P2X7 Receptor and NLRP3 Inflammasome

This study identifies Paxillin's role in promoting ATP-induced activation of P2X7 receptor and NLRP3 inflammasome through complex formation and deubiquitination.

STING recruits NLRP3 to the ER and deubiquitinates NLRP3 to activate the inflammasome

This study shows STING activates the NLRP3 inflammasome by recruiting NLRP3 to the ER and deubiquitinating it, enhancing IL-1β secretion and inflammatory responses.

Pan-genome analysis reveals the molecular basis of niche adaptation of Staphylococcus epidermidis strains

This study analyzes the pan-genome of Staphylococcus epidermidis to identify genomic factors associated with its adaptation to diverse niches and pathogenicity.