Author

P. Sirven

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Research Focus:cell type annotation· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:imaging· 1

Frequent Co-Authors

A. Surun· 2 shared C. Hoffmann· 2 shared C. Le Tourneau· 2 shared C. Lecerf· 2 shared H. Salmon· 2 shared J. Klijanienko· 2 shared M. Guillot-Delost· 2 shared M. Kamal· 2 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersCancer Biology

A. Surun

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

How cancer-associated fibroblasts promote T-cell exclusion in human lung tumors: a physical perspective

J. Ackermann, C. Bernard, P. Sirven, H. Salmon, M. Fraldi, M. Ben Amar

The paper models how cancer-associated fibroblasts in lung tumors create barriers that exclude T-cells, affecting tumor growth and immune response outcomes.

bioRxiv · Jan 16, 2024 · PreprintBiophysics

Spatial positioning and matrix programs of cancer-associated fibroblasts promote T cell exclusion in human lung tumors

J. A. Grout, P. Sirven, A. M. Leader, S. Maskey, E. Hector, I. Puisieux, F. Steffan, E. Cheng, N. Tung, M. Maurin, R. Vaineau, L. Karpf, M. Plaud, M. Casanova-Acebes, A. Tabachnikova, , H. Salmon

The paper identifies two CAF subsets in human lung tumors that promote T cell exclusion through distinct matrix programs and spatial organization.

bioRxiv · Jan 20, 2022Cancer Biology

MMP2 As An Independent Prognostic Stratifier In Oral Cavity Cancers

C. Hoffmann, S. Vacher, P. Sirven, C. Lecerf, L. Massenet, A. Moreira, A. Surun, A. Schnitzler, J. Klijanienko, O. Mariani, E. Jeannot, N. Badois, M. Lesnik, O. Choussy, C. Le Tourneau, , V. Soumelis

The paper identifies MMP2 as an independent prognostic biomarker for oral cavity cancers, associated with poor disease-specific survival.

bioRxiv · Aug 2, 2019Cancer Biology

PDL1 AND ICOSL DISCRIMINATE HUMAN SECRETORY AND HELPER DENDRITIC CELLS

C. Hoffmann, F. Noel, M. Grandclaudon, P. Michea, A. Surun, L. Faucheux, P. Sirven, J. Rochefort, O. Lantz, J. Klijanienko, C. Lecerf, M. Kamal, C. Le Tourneau, M. Guillot-Delost, V. Soumelis

The paper identifies two functional states of human activated dendritic cells, secretory DC and helper DC, distinguished by PDL1 and ICOSL expression and their distinct cytokine profiles and T cell stimulation capacities.

bioRxiv · Aug 1, 2019 · PreprintImmunology