Cardiomyocyte PGC-1α enables physiological adaptations to endurance exercise through suppression of GDF15 and cardiac atrophy
S. A. Khetarpal, H. Li, T. Vitale…·A. Rosenzweig
This study shows that cardiomyocyte PGC-1α is essential for cardiac adaptation to endurance exercise by suppressing GDF15 and preventing cardiac atrophy in mice.