Extent, impact, and mitigation of batch effects in tumor biomarker studies using tissue microarrays
K. H. Stopsack, S. Tyekucheva, M. Wang, T. A. Gerke, J. B. Vaselkiv, K. L. Penney, P. W. Kantoff, S. P. Finn, M. Fiorentino, M. Loda, T. L. Lotan, G. Parmigiani, L. A. Mucci
This study assesses batch effects in TMA-based cancer biomarker studies and shows mitigation methods reduce variance and alter clinical associations.
bioRxiv · Jun 29, 2021Pathology