Alanine scanning mutagenesis of the Suvratoxumab epitope reduces alpha toxin lytic activity in vitro and S. aureus fitness in infection models
C. Tkaczyk, E. Semenova, Y. Shi, K. Rosenthal, V. Oganesyan, P. Warrener, K. Stover, B. R. Sellman
The paper mutates nine residues in the Suvratoxumab epitope of alpha toxin, showing reduced lytic activity and bacterial fitness, supporting the epitope's role in toxin function.
bioRxiv · May 16, 2018Microbiology