Structural and binding studies of human CAMKK2 kinase domain bound to small molecule ligands
G. S. Profeta, C. V. dos Reis, P. H. Godoi, A. M. Fala, R. Satori, A. P. Salmazo, P. Z. Ramos, K. B. Massirer, J. M. Elkins, D. H. Drewry, O. Gileadi, R. M. Counago
This study presents six novel co-structures of CAMKK2 bound to small molecule ligands and shows some ligand binding is enthalpy driven.
bioRxiv · Feb 1, 2019 · PreprintBiochemistry