Author
Primary ORCID profile (0000-0001-6886-898X · 14 papers)Unclaimed ORCID profile · follow to get notified of new preprints
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
9 papers
Recent·Most cited
W. J. Bradshaw, E. C. Kennedy, T. Moreira, L. A. Smith, R. Chalk, V. L. Katis, J. L. Benesch, P. E. Brennan, E. J. Murphy, O. Gileadi
The paper determines structures of SHIP1 and SHIP2 phosphatase and C2 domains, showing the C2 domain modulates phosphatase activity more in SHIP2 than SHIP1, providing insights for drug development.
bioRxiv · Jul 31, 2023Biochemistry
C. I. Wells, Y. Liang, T. L. Pulliam, C. Lin, D. Awad, B. Eduful, S. O Byrne, M. A. Hossain, C. Catta-Preta, P. Zonzini Ramos, O. Gileadi, C. Gileadi, R. M. Counago, B. Stork, C. G. Langendorf, , D. H. Drewry
This paper introduces SGC-CAMKK2-1, a selective chemical probe for CAMKK2, demonstrating its potential as a tool to study the therapeutic benefits of CAMKK2 inhibition.
Cells · Jan 11, 2023Peer-reviewedCancer Biology
H. T. Baddock, S. Brolih, Y. Yosaatmadja, M. Ratnaweera, M. Bielinski, L. Swift, A. Cruz-Migoni, G. M. Morris, C. J. Schofield, O. Gileadi, P. J. McHugh
This study characterizes the SARS-CoV-2 nsp14-nsp10 complex as an RNA nuclease, identifies its role in genome stability, and discovers inhibitors targeting this complex.
bioRxiv · Aug 13, 2020 · PreprintBiochemistry
G. L. Righetto, D. Sriranganadane, L. Halabelian, C. Gottschald Chiodi, J. Elkins, K. B. Massirer, O. Gileadi, M. Menossi, R. Counago
This study investigates the role of SnRK2-box and ABA-box domains in sugarcane SnRK2s auto-activation and activity, revealing distinct regulatory mechanisms compared to Arabidopsis.
bioRxiv · Mar 26, 2019Plant Biology
R. Chalk, O. Borkowska, K. A. Azeez, S. Oerum, P. Born, O. Gileadi, N. Burgess-Brown
The paper examines how electrospray mass/charge distributions reflect protein surface area and molecular motion, showing differences between native and denatured proteins.
bioRxiv · Mar 8, 2019 · PreprintBiophysics
G. S. Profeta, C. V. dos Reis, P. H. Godoi, A. M. Fala, R. Satori, A. P. Salmazo, P. Z. Ramos, K. B. Massirer, J. M. Elkins, D. H. Drewry, O. Gileadi, R. M. Counago
This study presents six novel co-structures of CAMKK2 bound to small molecule ligands and shows some ligand binding is enthalpy driven.
bioRxiv · Feb 1, 2019 · PreprintBiochemistry
A. d. S. Santiago, R. M. Counago, P. Zonzini Ramos, P. H. C. Godoi, K. B. B. Massirer, O. Gileadi, J. Elkins
The paper determines the crystal structure of CAMKK1 with inhibitors and identifies structural differences from CAMKK2 to guide the design of specific inhibitors.
bioRxiv · Mar 31, 2018Biochemistry
R. M. Counago, C. K. Allerston, P. Savitsky, H. Azevedo, P. H. Godoi, C. I. Wells, A. Mascarello, F. H. de Souza Gama, K. B. Massirer, W. J. Zuercher, C. R. W. Guimaraes, O. Gileadi
The paper identifies BI-D1870 as a starting point for VRK inhibitors and reports co-crystal structures revealing different P-loop conformations in VRK1 and VRK2.
bioRxiv · Mar 2, 2017Biochemistry
D. H. Drewry, C. I. Wells, D. M. Andrews, R. Angell, H. Al-Ali, A. D. Axtman, S. J. Capuzzi, J. M. Elkins, P. Ettmayer, M. Frederiksen, O. Gileadi, N. Gray, A. Hooper, S. Knapp, S. Laufer, , T. M. Willson
The paper shares progress on a kinase chemogenomic set, releases inhibitor profiling data, and calls for community collaboration to complete the set.
bioRxiv · Jan 31, 2017Pharmacology & Toxicology