Myonuclear loss, rather than senescent myonuclei, associates with fiber type-specific atrophy in aging human skeletal muscle
Carlos S. Zepeda, Isabell Dobrzycki, Paige Acklie, Cory M. Dungan, Ronald G. Jones, Kevin A. Murach, Christopher W. Sundberg
This study shows that myonuclear loss, not senescent myonuclei, is linked to fast fiber atrophy in aging human skeletal muscle.
bioRxiv · Feb 13, 2026 · PreprintCell Biology