Developmental Characterization of Neuronal Migration Anomalies and Axon Proliferation in mTOR pathway-associated Malformations of Cortical Development
Paige B. Hoffman, Matthew N. Svalina, Chiara A. Flores, Christine R. Brzezinski, J. Keenan Kushner, Brandon L. Staple, Santos J. Franco, Allyson Alexander
This study uses in utero electroporation to induce mTOR pathway dysregulation in rodents, revealing early developmental abnormalities in neuronal migration and axon proliferation linked to malformations of cortical development.
bioRxiv · Mar 11, 2023 · PreprintNeuroscience