Repression of Transcription Factor AP-2 Alpha by Peroxisome Proliferator Activated Receptor Gamma Reveals a Novel Transcriptional Circuit in basal-squamous Bladder Cancer
Hironobu Yamashita, Yuka Imamura Kawasawa, Lauren Shuman, Zongyu Zheng, Truc Tran, Vonn Walter, Joshua I. Warrick, Hikmat Al-Ahmadie, Matthew Kaag, Pak Kin Wong, Jay D. Raman, David J. DeGraff
This study identifies PPARγ repression of TFAP2A and TFAP2C as drivers of the aggressive basal-squamous bladder cancer subtype through RNA-seq and functional analysis.
bioRxiv · Sep 7, 2018 · PreprintCancer Biology