Author

David J. DeGraff

Pennsylvania State UniversityORCID 0000-0002-7154-7594Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:Hi-C· 1 Approach:statistical model· 1

Frequent Co-Authors

Hironobu YamashitaiD· 2 shared Jay D. RamaniD· 2 shared Joshua I. WarrickiD· 2 shared Baozhen ZhangiD· 1 shared Fan Song· 1 shared Feng YueiD· 1 shared Hikmat Al-Ahmadie· 1 shared Hongbo YangiD· 1 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersGenomics

Hironobu YamashitaORCID

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2 papers

Recent·Most cited

Subtype-specific epigenomic landscape and 3D genome structure in bladder cancer

Tejaswi Iyyanki, Baozhen Zhang, Qixuan Wang, Ye Hou, Qiushi Jin, Jie Xu, Hongbo Yang, Tingting Liu, Xiaotao Wang, Fan Song, Yu Luan, Hironobu Yamashita, Ruby Chien, Huijue Lyu, Lijun Zhang, , Feng Yue

This study identifies subtype-specific epigenomic and 3D genome structures in bladder cancer, linking NPAS2 to luminal subtype regulation and clinical outcomes.

Genome biology · Apr 15, 2021Peer-reviewedGenomics

Repression of Transcription Factor AP-2 Alpha by Peroxisome Proliferator Activated Receptor Gamma Reveals a Novel Transcriptional Circuit in basal-squamous Bladder Cancer

Hironobu Yamashita, Yuka Imamura Kawasawa, Lauren Shuman, Zongyu Zheng, Truc Tran, Vonn Walter, Joshua I. Warrick, Hikmat Al-Ahmadie, Matthew Kaag, Pak Kin Wong, Jay D. Raman, David J. DeGraff

This study identifies PPARγ repression of TFAP2A and TFAP2C as drivers of the aggressive basal-squamous bladder cancer subtype through RNA-seq and functional analysis.

bioRxiv · Sep 7, 2018 · PreprintCancer Biology