Exploring the kinetic selectivity of antipsychotics for dopamine D2 and 5-HT2A receptors: implications for the prevalence of EPS and receptor occupancy
David A. Sykes, Jack M. Lochray, Hannah M.F. Comfort, Palash Jain, Steven J. Charlton
This study measures the kinetic binding properties of antipsychotics at 5-HT2A and D2 receptors and correlates them with extrapyramidal side effects (EPS) at therapeutic doses.
bioRxiv · Nov 14, 2021 · PreprintNeuroscience