Deep mapping of structural perturbations to energetics enables precise TCR design
Shifu Luo, Songming Zhang, Ying Shi, J W Li, Jiaxin Cai, Ning‐Yi Shao, Pan Yanchun
The paper introduces mpTCRai, a deep learning framework that maps structural perturbations to energetic changes in TCRs, enabling precise and safe TCR design for immunotherapy.
Cell Reports Methods · Aug 20, 2026Peer-reviewedImmunology