Author

Shifu Luo

Chinese Academy of SciencesORCID 0000-0001-9735-4670Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:contrastive learning· 1 Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Approach:graph neural network· 1 Research Focus:GWAS / association mapping· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Songming ZhangiD· 2 shared Ying Shi· 2 shared J W LiiD· 1 shared Jiaxin Cai· 1 shared Jinyan LiiD· 1 shared Ling Liu· 1 shared Ning‐Yi ShaoiD· 1 shared Pan Yanchun· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

Songming ZhangORCID

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2 papers

Recent·Most cited

ImmunologyCell Reports MethodsPeer-reviewedAug 20, 2026

Deep mapping of structural perturbations to energetics enables precise TCR design

Shifu Luo, Songming Zhang, Ying Shi…·Pan Yanchun

The paper introduces mpTCRai, a deep learning framework that maps structural perturbations to energetic changes in TCRs, enabling precise and safe TCR design for immunotherapy.

DOI 10.1016/j.crmeth.2026.101569

humanproteomics

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BioinformaticsbioRxivPreprintAug 10, 2026

Mapping disease traits onto spatiotemporal domain landscapes through scalable multi-sample integration of spatial transcriptomics

Songming Zhang, Shifu Luo, Yuxiao Luo…·Jinyan Li

STUltra integrates spatial transcriptomics data to map disease traits onto spatiotemporal tissue landscapes, outperforming existing methods in scalability and speed.

DOI 10.64898/2025.12.15.694341

mousespatial transcriptomics

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