Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor
Xiangjun Zhao, Chaowen Yu, Antony D. Adamson, Aite Zhao, Huiyu Zhou, Pankaj Sharma, Tao Wang
This study identifies a selective vulnerability of cerebral vascular smooth muscle cells to NOTCH3 variants in small vessel disease and shows that PDE5 inhibition can rescue the dysfunction.
bioRxiv · May 30, 2025 · PreprintNeuroscience