Tao Wang

This study identifies HTRA1 deficiency in COL4A1 mutant astrocytes as a mechanism underlying BBB dysfunction in cerebral small vessel disease.

This study identifies a selective vulnerability of cerebral vascular smooth muscle cells to NOTCH3 variants in small vessel disease and shows that PDE5 inhibition can rescue the dysfunction.

This study identifies cognitive impairment and white matter defects in a mouse model of cerebral small vessel disease caused by Col4a1 mutations and shows that targeting protein folding can alleviate these issues.

This study develops bioengineered blood vessels from iPSC-derived cells and silk fibroin-coated scaffolds, showing mechanical and structural properties similar to autologous grafts.

This study shows that Notch3 deletion reduces HIV-1 gene expression and systemic inflammation, improving outcomes in HIV-associated chronic kidney disease.