NeurosciencebioRxivPreprint
Selective vulnerability of cerebral vasculature to NOTCH3 variants in small vessel disease and rescue by phosphodiesterase-5 inhibitor
Xiangjun Zhao, Chaowen Yu, Antony D. Adamson…·Tao Wang
This study identifies a selective vulnerability of cerebral vascular smooth muscle cells to NOTCH3 variants in small vessel disease and shows that PDE5 inhibition can rescue the dysfunction.
DOI 10.1101/2025.05.30.656914