Improved De Novo Peptide Binder Design with Target-Conditioned Inverse Folding
Elliot Layne, Ashlin K Kanawaty, Aron Broom, Alexander Kitaygorodsky, Anita K. Nivedha, Parth Vora, Caroline Woffindale, Sarah Hailstone, Eirini Sachouli, Ella Halcrow, Gillian E. Donachie, Michelle Adsett, Glenn L. Butterfoss, Mark Fingerhuth
This paper improves de novo peptide binder design by combining peptide-specific finetuning with a novel decoding order strategy, achieving a 16-30% increase in in silico success rates and doubling top-ranking agonists for OPRM1.
bioRxiv · Oct 28, 2025 · PreprintBioengineering