Pedrum Mohammadi‐Shemirani

The paper performs whole exome sequencing on 44,028 British South Asians to identify gene-phenotype associations and knockout genes, finding novel links and implications for drug development.

The paper introduces BigRNA, an RNA foundation model that predicts RNA biology from DNA sequence and identifies therapeutic effects of SBOs on gene expression and splicing.

This study identifies 73 genetic loci associated with blood mitochondrial DNA copy number and suggests a causal link between low mtDNA-CN and dementia risk.

The paper develops a method to create calibrated rare variant genetic risk scores using exome data, showing strong association with coronary artery disease risk.

This study uses Mendelian randomization to assess the effects of genetically elevated free testosterone on 23 health outcomes, finding both clinical benefits and adverse effects.