IL-27 neutralization promotes pro-inflammatory macrophage polarization and improve response to immune checkpoint blockade
Quentin Glaziou, Laëtitia Basset, Sènan Mickaël D'Almeida, Pascale Pignon, Christophe Blanquart, Yves Delneste, Julie Tabiasco
This study shows that blocking IL-27 reduces CD39 expression in tumor cells and enhances anti-PD-L1 therapy effectiveness.
bioRxiv · Sep 13, 2024 · PreprintImmunology