Isoflavones impair response to anti-PD1 therapy in murine breast cancer models, irrespective of dietary fiber and fecal short chain fatty acid levels
Fábia de Oliveira Andrade, Kerrie B. Bouker, Melike Özgül Önal, Lu Jin, Idalia Cruz, William Helferich, Audrey Gao, Karla Andrade, Vivek Verma, Christopher Staley, Patricia L Foley, Leena Hilakivi-Clarke
This study shows that isoflavones in the diet impair anti-PD1 therapy response in breast cancer models, regardless of dietary fiber or SCFA levels, and that ER blockade can restore responsiveness.
bioRxiv · Dec 9, 2025 · PreprintCancer Biology