Cancer BiologybioRxivPreprint
Isoflavones impair response to anti-PD1 therapy in murine breast cancer models, irrespective of dietary fiber and fecal short chain fatty acid levels
Fábia de Oliveira Andrade, Kerrie B. Bouker, Melike Özgül Önal…·Leena Hilakivi-Clarke
This study shows that isoflavones in the diet impair anti-PD1 therapy response in breast cancer models, regardless of dietary fiber or SCFA levels, and that ER blockade can restore responsiveness.
DOI 10.64898/2025.12.05.692375