Li Ma

A gastric microbial chromatin remodeler drives gastric cancer progression and immune evasion by reprogramming the host epigenome

This study identifies Streptococcus anginosus as a gastric cancer driver that uses a chromatin remodeler to reprogram host epigenomes and promote immune evasion.

4-Phenylbutyrate Rescue in GABRA1 Variants Associated with Developmental Epileptic Encephalopathies: from Cell and Mouse Models to Human

This study tests the therapeutic effect of 4-phenylbutyrate (PBA) on GABRA1 variants associated with developmental epileptic encephalopathies using cell and mouse models, showing improved receptor expression and function.

Molecular Mechanisms Limiting the Therapeutic Window of AAV Gene Therapy in Mouse Models of Blue Cone Monochromacy

This study evaluates AAV gene therapy in BCM mouse models, finding that older mutant mice show reduced treatment efficacy due to decreased transduction and cone degeneration, while specific promoters remain active.

Integrating large-scale meta-GWAS and PigGTEx resources to decipher the genetic basis of complex traits in pig.

The paper performs a multi-breed meta-GWAS in pigs to identify genomic regions associated with complex traits and integrates with PigGTEx to prioritize variant-gene-tissue-trait circuits.

KDM6A facilitates Xist upregulation at the onset of X inactivation

This study shows that KDM6A is required for Xist upregulation during X inactivation initiation in mouse ES cells, as its knockout impairs Xist RNA coating and leads to aberrant Xi gene expression.

Methyltransferase-like 3 modulates severe acute respiratory syndrome coronavirus-2 RNA N6-methyladenosine modification and replication

This study shows that SARS-CoV-2 RNA undergoes N6-methyladenosine modification, and host METTL3 interacts with viral RdRp to modulate viral replication.

Systems Biology Analysis Using A Genome-Scale Metabolic Model Shows That Phosphine Triggers Global Metabolic Suppression In A Resistant Strain Of C. elegans

The paper uses a genome-scale metabolic model and metabolomics to show phosphine resistance in C. elegans is linked to hypometabolic adaptation via DLD.

XWAS: a software toolset for genetic data analysis and association studies of the X chromosome

XWAS provides tools for X chromosome analysis in GWAS, identifying new genetic associations in immune disorders and coronary artery disease risk factors.

Accounting for eXentricities: Analysis of the X chromosome in GWAS reveals X-linked genes implicated in autoimmune diseases

The paper analyzes the X chromosome in GWAS to identify X-linked genes associated with autoimmune diseases, finding several genes linked to conditions like Crohn's disease and ulcerative colitis.