Engineering Brain Parasites for Intracellular Delivery of Therapeutic Proteins
Shahar Bracha, Karoliina Hassi, Paul D. Ross, Stuart Cobb, Lilach Sheiner, Oded Rechavi
This paper engineers Toxoplasma gondii to deliver therapeutic proteins to the CNS by fusing them to the parasite's secretory proteins, demonstrating potential for intracellular delivery of treatments for neurological disorders.
bioRxiv · Dec 3, 2018 · PreprintSynthetic Biology