An evolutionarily conserved role for VEGF signaling in the expansion of non-vascular tissue during regeneration.
Aaron M. Savage, Alexandra C. Wagner, Ryan T. Kim, Paul Gilbert, Hani D. Singer, Erica Chen, Elane M. Kim, Noah Lopez, Kelly E. Dooling, Julia C. Paoli, S. Y. Celeste Wu, Sebastian Bohm, Rachna Chilambi, Tim Froitzheim, Steven J. Blair, , Jessica L. Whited
This study shows VEGF signaling is essential for salamander limb regeneration and blastema expansion, independent of angiogenesis, and functions upstream of EMT transcription factors.
bioRxiv · Oct 1, 2024 · PreprintDevelopmental Biology