Exosome-mediated LNA anti-miR delivery achieves potent miR-21 inhibition and PTEN restoration in podocytes.
Tim Lange, Joanne Ern Chi Soh, Lea-Katharina Friedrich, Paul Luca Goetsch, Claudia Weber, Doreen Biedenweg, Rabea Schlueter, Una Janke, Mihaela Delcea, Nicole Endlich
This paper demonstrates that exosome-mediated delivery of LNA anti-miR-21 achieves efficient miR-21 inhibition and PTEN restoration in podocytes, overcoming the limitations of free oligonucleotide uptake.
bioRxiv · Jul 17, 2026 · PreprintCell Biology