Tim Lange

Exosome-mediated LNA anti-miR delivery achieves potent miR-21 inhibition and PTEN restoration in podocytes.

This paper demonstrates that exosome-mediated delivery of LNA anti-miR-21 achieves efficient miR-21 inhibition and PTEN restoration in podocytes, overcoming the limitations of free oligonucleotide uptake.

Glomage: A multimodal platform for high-content morphological and RNA profiling of glomeruli in zebrafish and mouse models

Glomage enables high-throughput analysis of glomeruli in zebrafish and mouse models, combining morphological and RNA profiling to study podocyte changes and drug responses.

Regulation of the transcriptome, miRNAs, and alternative splicing in a FSGS zebrafish injury model

This study investigates alternative splicing and miRNA regulation in a zebrafish FSGS model, identifying key splicing events and miRNAs associated with disease progression.

Efficient delivery of small RNAs to podocytes in vitro by direct exosome transfection.

This study demonstrates that directly transfected exosomes can deliver small RNAs to podocytes in vitro, showing efficient cargo uptake and functional effects.

Evaluation of endogenous miRNA reference genes across different zebrafish strains, developmental stages and kidney disease models

This study evaluates miRNA reference genes in zebrafish across strains, developmental stages, and kidney disease models, identifying dre-miR-92b-3p as the most stable reference gene.