Nicole Endlich

This paper demonstrates that exosome-mediated delivery of LNA anti-miR-21 achieves efficient miR-21 inhibition and PTEN restoration in podocytes, overcoming the limitations of free oligonucleotide uptake.

Glomage enables high-throughput analysis of glomeruli in zebrafish and mouse models, combining morphological and RNA profiling to study podocyte changes and drug responses.

This study investigates alternative splicing and miRNA regulation in a zebrafish FSGS model, identifying key splicing events and miRNAs associated with disease progression.

This study identifies MAGI2 as a conserved biomarker for podocyte injury, showing its downregulation in glomerular diseases and differential expression in primary vs secondary FSGS.

The paper investigates alternative splicing in mechanically stretched podocytes, identifying splicing events in Shroom3 and Myl6 that may contribute to hypertensive nephropathy.

This study demonstrates that directly transfected exosomes can deliver small RNAs to podocytes in vitro, showing efficient cargo uptake and functional effects.

This study investigates ILDR2's role in glomerulopathies, finding it upregulated in disease models and suggesting a protective effect against glomerular damage.

This paper demonstrates that synthetic CTNS mRNA therapy can restore cystinosin function and reduce cystine accumulation in kidney cells and zebrafish models of cystinosis.

This study uses human pluripotent stem cell-derived kidney organoids to model nephrotic syndrome, showing they can replicate podocyte injury and respond to genetic correction.

This study evaluates miRNA reference genes in zebrafish across strains, developmental stages, and kidney disease models, identifying dre-miR-92b-3p as the most stable reference gene.