Author

Paul R. Hess

University of PennsylvaniaPrimary ORCID profile (0000-0002-8146-547X · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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Same name, identified by ORCID

Paul R. HessiD1 paper · North Carolina State University

Biology Disciplines

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Bioinformatics· 1 Genomics· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Organism:rat· 1 Assay:scATAC-seq· 1

Frequent Co-Authors

Nancy Ruonan ZhangiD· 2 shared Alexander C. Huang· 1 shared Allen WangiD· 1 shared Andrew E. DavisiD· 1 shared Anuja SatheiD· 1 shared Billy T. LauiD· 1 shared Bing ReniD· 1 shared Charlene MicianoiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersGenomics

Nancy Ruonan ZhangORCID

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2 papers

Recent·Most cited

A Measure of Transcriptional Dyscoordination for Quantifying Aging in Single Cells

Yilin Yang, Paul R. Hess, Xinyi E. Chen, Sijia Huang, Marcos G. Teneche, Hanzhi Wang, Karl N. Miller, Andrew E. Davis, Charlene Miciano, Kelly Yichen Li, Sainath Mamde, Kevin Yuk-Lap Yip, Bing Ren, Qian Yang, Elizabeth W. Smoot, , Nancy Ruonan Zhang

This paper introduces a measure of transcriptional dyscoordination to quantify aging in single cells, showing it increases with age and is linked to cellular processes like senescence and genome instability.

bioRxiv · Oct 7, 2026 · PreprintGenomics

Cancer subclone detection based on DNA copy number in single cell and spatial omic sequencing data

Chi-Yun Wu, Jiazhen Rong, Anuja Sathe, Paul R. Hess, Billy T. Lau, Susan M. Grimes, Sijia Huang, Hanlee P. Ji, Nancy Ruonan Zhang

Clonalscope detects cancer subclones using DNA copy number data from single-cell and spatial omic sequencing, identifying spatially segregated subclones and validating them with matched scDNA-seq data.

Nature Methods · Sep 1, 2025Peer-reviewedBioinformatics