Andrew E. M. Davis

A Measure of Transcriptional Dyscoordination for Quantifying Aging in Single Cells

This paper introduces a measure of transcriptional dyscoordination to quantify aging in single cells, showing it increases with age and is linked to cellular processes like senescence and genome instability.

A novel transgenic reporter to study vertebrate epigenetics

The paper introduces an EpiTag zebrafish transgenic reporter to visualize epigenetic silencing/activation and identifies tissue-specific epigenetic regulatory genes through mutagenesis screening.

Anatomical and Molecular Characterization of the Zebrafish Meninges

This paper characterizes the zebrafish meninges using single-cell transcriptomics, identifying a novel cell type essential for brain development.

The reparative immunologic consequences of stem cell transplantation as a cellular therapy for refractory Crohn's disease

This study investigates how stem cell transplantation (SCT) restores immune function in refractory Crohn's disease by analyzing immune cell remodeling and HSC heterogeneity using single-cell RNA sequencing and functional assays.

Regulation of angiogenesis by endocytic trafficking mediated by cytoplasmic dynein 1 light intermediate chain 1

This study shows that LIC1 and RILPL1/2 restrict angiogenesis by promoting VEGFR2 degradation, and their disruption increases angiogenesis through enhanced Rab11-mediated recycling.

Profiling the endothelial translatome in vivo using 'AngioTag' zebrafish

The paper introduces a zebrafish transgenic line to profile endothelial cell translatomes in vivo, revealing novel genes and expression signatures across adult organs.

Activated Interferon Signaling Suppresses Age-Dependent Liver Cancer

This study shows that aged livers have heightened interferon signaling that suppresses cancer but also has harmful effects, leading to a 'precarious balance' in tumor development.

Rapid generation of pigment free, immobile zebrafish embryos and larvae in any genetic background using CRISPR-Cas9 dgRNPs

This paper demonstrates the use of CRISPR-Cas9 dgRNPs to generate pigment-free, immobile zebrafish embryos and larvae across genetic backgrounds, enhancing live imaging capabilities.

In vivo dissection of Rhoa function in vascular development using zebrafish

This study investigates the in vivo roles of RHOA in vascular development and integrity using zebrafish models, finding that both gain- and loss-of-function lead to vascular dysfunction.

MicroRNA-mediated control of developmental lymphangiogenesis

This study identifies miR-204 as a key regulator of lymphangiogenesis, showing its role in lymphatic vessel formation and its interaction with NFATC1.