A role of extracellular vesicle-mediated inter-organ communication in obesity-related arrhythmia
Worawan B. Limpitikul, Marta García-Contreras, Michael J. Betti, Paul Spangler, Quanhu Sheng, Steffen Pabel, Samuel Tobias Sossalla, Ling Xiao, Emeli Chatterjee, Patrick T. Ellinor, Eric R. Gamazon, Ravi V. Shah, Saumya Das
This paper shows that obesity-related extracellular vesicles from visceral adipose tissue impair cardiac function and contribute to arrhythmia by affecting cardiomyocytes, fibroblasts, and macrophages.
bioRxiv · Sep 13, 2025 · PreprintCell Biology